Tazobac® and beta-lactamase inhibitors
Classification
Tazobaktam belongs to a group of beta-lactamase inhibitors (also called beta-lactamase inhibitors). Most of these drugs are given in a fixed combination because this is how they can work best. Tazobactam is given in combination with piperacillin and is available under the trade name Tazobac®.
Further combinations would be amoxicillin + clavulanic acid, ampicillin + sulbactam, sultamicillin + sulbactam.
effect
All beta-lactamase inhibitors inhibit part of the bacterial enzyme beta-lactamase. This enzyme enables the bacteria to break down the beta-lactam ring of beta-lactam antibiotics (penicillin, Cephalosporin, Carbapenem) no longer inhibit. Thus the combination partners of the beta-lactamase inhibitors can work better.
Specialty
The preparations are usually given in combination with each other, which makes the effect against bacteria more effective (Sulbactam + ampicillin, tazobactam + piperazillin, clavulanic acid + amoxycillin).
Side effects
In the combination tazobactam and piperacillin occur very often with the application diarrhea, Nausea, Vomit and rash on. More rarely, infections due to resistant germs, a reduced number of leukocytes in the blood (leucopenia), a reduced number of blood platelets (thrombopenia), hypersensitivity reactions, a headache, low blood pressure (hypotension), sleep disorders (Insomnia), inflammation of the veins (phlebitis), constipation, indigestion, inflammation of the lining of the mouth (stomatitis), an increase in liver enzymes, yellowing of the skin (Jaundice), Itching and rash, red skin (erythema), an increase in creatinine and a fever.
Please also read our article on this Antibiotic side effects
Areas of application
Tazobactam
- Enterococcus faecalis
- Staphylococcus aureus
- Staphylococcus epidermidis
- Staphylococcus haemolyticus
- Staphylococcus hominis
- Staphylococcus agalacticae
- Staphylococcus pneumoniae
- Staphylococcus pyogenes.
One of the treatable gram-negative germs
- Eikenella corrodens
- Acinetobacter baumanii
- Escherichia coli
- Haemophilus influenzae
- Klebsiella Pneumoniae
- M. Catarrhalis
- M.morganii
- P. Mirabillis
- P. Vulgaris
- Pseudomonas aeroginosa
Anaerobically growing bacteria can also be treated with tazobactam (Tazobac) (Bacteroides fragilis Chlamydia spp. Fusobacterium spp. Mycoplasma spp.)
Especially Infections of the gastrointestinal tract (secondary peritonitis / peritonitis, cholangitis, cholecystitis,Diverticulitis, abscess in the abdominal cavity) and respiratory diseases (outpatient or hospital-acquired lung infection) are fought with tazobactam.
But also Soft tissue infections of the skin (e.g. Pressure ulcer or diabetic foot syndrome) belong to the area of application of Tazobac®.
Interactions
With simultaneous administration of blood thinners (anticoagulants), e.g. aspirin or Marcumar the effect may be increased. Oral contraceptives in conjunction with tazobactam (Tazobac®) may reduce the effectiveness of the "pill" come. When combined with drugs from the group of muscle relaxants, can have an increased effect with blockade of the Muscles and poor walking and standing can result.
Contraindications
Tazobactam should not be given if the patient is allergic to penicillin. At Pregnant women and at lactating Patients should receive treatment with Tazobac® only take place after a precise indication is given.
For more information, ask in your pharmacy.
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