CATECHOLAMINES

introduction

The catecholamines, also known as catecholamines, belong to the group of hormones with androgenic effects on the cardiovascular system. The catecholamines are so-called sympathomimetics endogenous or artificially synthesized substances and act on the alpha and beta receptors.
The catecholamines include:

adrenaline

Norepinephrine

Dopamine

Isoprenaline (Drug)

Dobutamine (Drug)

Dopeaxamine (Drug)

synthesis

The biosynthesis of Catecholamine takes place in the Adrenal gland and the Nervous system. First the amino acid Tyrosine increases with the help of the enzyme tyrosine hydroxylase Levodopa transformed. With the help of the amino acid decarboxylase, the so-called dopamine is produced from dopa. The Dopamine is in the next step by the dopamine hydroxylase in Norepinephrine transformed. In the last step, this is transformed by noradrenaline - N-methyltransferase adrenaline. The catecholamines are broken down by Renalase.

Areas of application

Catecholamines are in the form of drugs adrenaline, Norepinephrine and Dobutamine used. The catecholamines are only used in emergency medicine for cardiopulmonary resuscitation, allergic overreactions and states of shock. Administration is usually intravenous. Overdosing (wrong dosage form) can lead to Heart attacks or Cerebral hemorrhage come.

Catecholamines include adrenaline (Epinephrine) and norepinephrine (Norepinephrine), which are known as stress hormones.