Zyloric®

introduction

Zyloric® is a well-known drug that belongs to the group of uricostatic agents and, as a xanthine oxidase inhibitor, is able to influence the breakdown of organic purine bases into uric acid.
The active ingredient in Zyloric® is allopurinol.

It is used in most cases to treat chronic gout and is one of the most effective drugs for this condition.
Zyloric® has become an indispensable part of the pharmaceutical market due to its enormous treatment success.

Gout is an extremely painful joint disease caused by increased uric acid concentration and the associated storage of crystallized salts and urate in the joints.

Mechanism of action

Zyloric® works inhibits the breakdown of the organic purine base to uric acid out. This inhibitory effect is mediated by a reduction in the enzyme xanthine oxidase, which ultimately causes the Limited uric acid formation.
Thanks to this mechanism of action, Zyloric® can enormous decrease in uric acid concentration in the blood effect, which in turn means that less uric acid is available for metabolic processes in the tissue cells.
The starting materials (precursors) of uric acid cannot damage the organism and can easily be excreted through the kidneys.

In many cases, Zyloric® is used to treat a existing hyperuricemia (increased uric acid concentration in the blood) or after an acute Attack of gout used.
In addition, this drug is very successful in the therapy of Gouty nephropathies or uric acid stones.

application areas

Zyloric® is used in everyday clinical practice for the treatment of a wide variety of diseases and, due to its high therapeutic success, it is no longer possible to imagine the pharmaceutical market without it.
In patients with a increased levels of uric acid in the blood (primary hyperuricemia> 8.5 mg / dl) Zyloric® can be used for Gout prevention to lead.
Since gout is triggered by the increased uric acid concentration and the associated storage of crystallized salts and urate in the joints, one can Prevent gout by lowering the uric acid concentration in the blood as early as possible.
Zyloric® is also successfully used in secondary hyperuricemia caused by various previous illnesses and / or previous medical treatments.
Furthermore, patients can use existing urate nephropathy can be effectively helped by taking this medicine. Urate nephropathy is a hereditary disease in the Uric acid stored in kidney tissue and there too Uric acid stones is implemented. In most cases, these uric acid stones are deposited in the urinary tract.
In addition, Zyloric® can be used for Prevents the formation of calcium oxalate stones can be used.

For patients who have a Renal failure This drug may suffer not applied become. Likewise, during the pregnancy and the subsequent Lactation Do not take allopurinol.

Side effects of Zyloric

Commonly identified adverse drug reactions from Zyloric® include allergic skin reactions, which through Redness, strong itching and Blistering to make noticable.
Furthermore, many patients report the occurrence of nausea and Vomit in connection with the use of allopurinol.
Also the Formation of important blood cells is often negatively influenced by the active ingredient (leukopenia), pronounced deficiency symptoms can occur in the course of use.
Since kidney stones have developed in many patients, it is strongly recommended that they increase the normal amount of water you drink during the therapy phase, because a lot of fluid intake greatly reduces the risk of kidney stone formation.
Other side effects that cannot be neglected are Damage to the liver and Kidney disease.
Zyloric® should therefore not be taken or only taken under strict medical supervision if the patient has pre-existing conditions.

Interactions

The drug Zyloric® can Strongly affect the effect of many drugsFor this reason it must be clarified with the attending physician whether and to what extent before taking it other necessary medications adjusted Need to become.

Zyloric® enhances the effects of various anticoagulant drugs (Anticoagulants). For this reason, it is particularly important to take Marcumar.
In most cases, the daily dose of the anti-coagulant must be reduced while using allopurinol.

Furthermore, the effect of Probenecid amplify. Probenecid is a drug which (just like allopurinol) for Lowering of too high a level of urea in the blood is applied and therefore in the Therapy of gout diseases plays a major role.

Particular caution is also required in patients with Chlorpropamide, one Sulfonylureawho to Diabetes treatment is used. The effectiveness of this medicinal product is also increased when you take Zyloric® at the same time.

Various Anti-epileptic drugs (especially Phenytoin) that inhibit the excitability of Neurons serve and in this way to treat Epilepsies can be used, must urgently be re-dosed when Zyloric® is administered.

Stevens Johnson Syndrome

Although Zyloric® has an important position in medicine and has achieved great success in the treatment of gout, side effects cannot be ruled out. When prescribing this drug, the attending physician must always weigh up whether the clinical benefit outweighs the risk of side effects.

A possible complication in connection with taking Zyloric® is the occurrence of the so-called Stevens-Johnson syndrome.
According to studies, allopurinol is actually the most common cause of this disease.
This is a severe drug reaction that manifests itself primarily on the skin, but is rare.
In the course of the disease, the epidermis becomes detached on up to 10% of the body surface.

More on this topic: Stevens Johnson Syndrome