Active ingredient



Nitrendipine belongs to a group of calcium channel blockers or calcium antagonists (antagonist - opponent). It is used to treat high blood pressure (arterial hypertension) and used as acute medication for blood pressure derailment (hypertensive emergency) (Bayotensin akut®). Within the group of calcium antagonists, nitrendipine belongs to the dihydropyridines. In contrast to other representatives of calcium channel blockers (e.g. verapamil, diltiazem), it only attacks the blood vessels and hardly the heart, which is important for the indication and the spectrum of side effects.

Side effects

Typical side effects of Bayotensin® are those caused by the blood vessel expanding effect. So can a fit Redness and overheat of the skin of face and upper body (Flush) occur, as well a headache, dizziness, fatigue, tingle in Poor and Legs (Paresthesia) and water retention in the legs (lower leg edema).

Also a Trembling of hands (tremor) was reported. It can continue to develop Angina pectoris Seizures (attacks of Chest pain through temporary Circulatory disorder of the heart) or - in the case of pre-existing angina pectoris - these complaints become worse. Also a faster beating of the heart (Tachycardia) and Palpitations (Palpitations) can occur. A very rare side effect is the development of one Heart attack by nitrendipine. Especially at the beginning of treatment, there may be an increase in urine output (Polyuria). Also nausea and Flatulence can occur.
Due to the mechanism of action, it can be excessive Lowering blood pressure (Hypotension) come.


Different drugs can be one Weakened effect of nitrendipine cause it to be a certain enzyme (CYP34A), which is responsible for the breakdown of nitrendipine. This means that nitrendipine is broken down more quickly. These drugs are called CYP inducersn denotes.
These include:

  • Rifampicin (antibiotic, mainly applied to the treatment of tuberculosis)
  • Anti-epileptic drugs
  • Phenytoin
  • Carbamazepine
  • Barbiturates
  • phenobarbital.

Other drugs, in turn, inhibit the enzyme (CYP34A) and lead to the fact that nitrendipine is broken down less quickly. They are known as CYP inhibitors.
These include drugs used to treat HIV (Protease inhibitors), Anti-epileptic drugs (Valproic acid), Antibiotics of the macrolide type, some drugs used to treat Fungal diseases (Antifungal drugs) and grapefruit juice. The effect of grapefruit juice can be enhanced for up to three days after it has been taken, so the consumption of grapefruit juice should be avoided during treatment.
Simultaneous use of nitrendipine and Beta blockers should be handled with care and only carried out with regular checks. Intravenous administration of beta-blockers when taking nitrendipine at the same time should be avoided.


Nitrendipine / Bayotensin® is available in tablet form and as a solution (Vials), whereby the solution for the treatment of hypertensive emergencies (blood pressure derailment) is used, the tablet for Treatment of high blood pressure. The usual daily tablet dose for high blood pressure is 20 mg Bayotensin®. Either one 10 mg tablet each morning and evening or one 20 mg tablet per day. The daily dose can be increased up to 40 mg if necessary. If the blood pressure is abnormal, a vial (1 ml solution with 5 mg nitrendipine) can be taken if necessary, after 30-60 minutes a second vial can be used if necessary.

Application / indications

Bayotensin (mite) ® is used to treat essential arterial hypertension (high blood pressure) used. Bayotensin akut® is used as an acute medication for lowering blood pressure in a hypertensive emergency (blood pressure derailment).


Bayotensin® / Nitrendipin must not be taken with:

  • known hypersensitivity to nitrendipine or other calcium antagonists from the group of dihydropyridines
  • Cardiovascular shock,
  • acute heart attack (and up to 4 weeks afterwards),
  • unstable angina pectoris
  • and low blood pressure (Hypotension).

It is still contraindicated during pregnancy and Lactation as well as in children.

Please also read our topic: Medication during pregnancy

Very careful use should be made in patients with Heart failure (Heart failure) respectively.
In chronic liver disease, the breakdown of nitrendipine can be delayed, so that a lower dose should be started here (10 mg per day).


On a private prescription, 98 tablets of nitrendipine á 10 mg (Bayotensin mite®) cost around 49 euros. 98 tablets of 20 mg nitrendipine (Bayotensin®) cost around 58 euros. If you have a prescription, 98 tablets of 10 mg cost 40 euros and 98 tablets of 20 mg cost 48 euros. 4 vials of 1 ml solution with 5 mg nitrendipine cost around 25 euros on a private prescription. If a prescription is available, only the prescription fee is due.