Hyaluronic acid used to treat joint diseases
English: hyaluronic acid
Orthopedic areas of application
Man-made Hyaluronic acid is also used in medicine, more precisely in the therapy of certain diseases. The main place of application for hyaluronic acid is Orthopedics.
Especially with from arthrosis afflicted Joints there is a degenerative deterioration of the Articular cartilage and des Joint. The joint cartilage is largely made up of hyaluronic acid. Is the cartilage at arthritic As the joints become worn and worn, an attempt can be made to inject hyaluronic acid synthesized outside the body into the joint space.
This should help the joint to become supple again and the joint movement is not hindered by friction. In the healthy joint, hyaluronic acid is permanently produced by fibroblasts (special connective tissue cells) located in the joint and in the joint cartilage. An artificial hyaluronic acid injected into the knee from the outside increases the hyaluronic acid component in the knee.
Diseased joints with degenerated cartilage (osteoarthritis) produce only a very reduced amount of hyaluronic acid themselves. Therefore, one tries to slow down the rapid breakdown of hyaluronic acid in the joint by repeated injections.
It will usually be between one to seven Hyaluronic acid injections administered. The half-life of hyaluronic acid, i.e. the time in which half of the substance has already been used, is approx. 60 hours. It is believed that the more frequent the injections are, the longer the half-life increases. However, the effectiveness after the injection is significantly higher, so that you can see an improvement in pain and mobility in the affected joint from months to years.
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Every treatment with hyaluronic acid must have one detailed explanation of the patient. Because like any procedure, there are also risks and side effects.
The injection itself takes place under the so-called sterile kauteln, so it is carried out under the same conditions as under a small operation.
First, the Injection site sufficient with disinfectant alcohol disinfected. The examiner, who wears sterile gloves himself, injects the hyaluronic acid as a finished preparation into the joint space. As a rule, the access route is from the outside under the Kneecap injected. The injection can also be divided and given half in the left joint space and half in the right joint space.
Mostly it becomes Anti-inflammatory also a Cortisone preparation additionally injected so that the inflammation in the joint can be minimized. Very rarely, even with all hygienic precautions, germs can get into the joint through the injection and one inflammation trigger. In this case it must be done immediately antibiotic treated, in very severe cases orthopedic surgery must be performed and the joint in a mirror (Arthroscopy) so that the germs can be eliminated.
Manufacture of hyaluronic acid
In orthopedics, but also in the rest of medicine, artificial hyaluronic acid, i.e. hyaluronic acid produced outside the body, is usually used
This is used in medicine synthesized salt of hyaluronic acid. Hyaluronic acid can also be produced by bacteria. Streptococcal cultures are usually used for this purpose.
There is no risk of germs being spread through artificial hyaluronic acids!
Animal hyaluronic acids are used less frequently. For medical use will Hyaluronic acid obtained from foreign tissue. Since mostly no fibroblasts that produce hyaluronic acid exist outside the human body, animal cells, which are particularly rich in hyaluronic acid, are mostly used.
If an animal hyaluronic acid production is chosen, Hahnenkamp is usually used. However, it must be noted that in some cases allergic reactions can occur if a Hypersensitivity compared to animal products.
The Hyaluronic acid is a biological molecule composed of various chemical building blocks that belongs to the group of proteoglycans.
sugar is an important part of this structure.The sugar parts can be linked to one another as long as you like and thus achieve a completely different length. The longer the chained molecules, the thicker and tougher the molecule becomes. The main occurrence of Hyaluronic acid is in the joints of the body, where it is needed as a lubricant primarily due to its shock-absorbing and lubricating effect. It is produced by so-called fibroblasts (special connective tissue cells) whose structure is similar to that of the Neurons strongly resembles and which can attach their processes to one another accordingly.
Fibroblasts are mostly near Joints to find. After the production of hyaluronic acid, quantities of this substance are regularly released into the joint space.
Other places of production and occurrences of hyaluronic acid are e.g. also the Band washers the human spine. The reason is that the substance, in addition to its lubricating and sliding effect, also creates tear resistance.
The molecule can be found everywhere where a lot of pressure has to be cushioned, especially in humans cartilage. Most of the force has to come from the body on the Spine be dispatched with every movement. For this reason, it makes sense that hyaluronic acid can also be found in and between the intervertebral discs.