Therapy of purulent meningitis

Synonyms in a broader sense

Bacterial meningitis, hood meningitis, convexity meningitis, leptomeningitis, meningococcal meningitis, antibiotic

Medical: purulent meningitis

English: meningitis, encephalitis, brain inflammation, brain-fever

definition

The term purulent meningitis (purulent meningitis) describes a purulent inflammation (-itis) of the meninges and spinal cord membranes (meninges), which can be triggered by different pathogens.
Purulent meningitis (purulent meningitis) is usually caused by bacteria. It is associated with a high fever and severe general clinical picture such as clouding of consciousness and represents an absolute emergency that must be treated immediately.

General information

General information on "What is meningitis?" can be found under our topic:

• Meningitis and
• purulent meningitis

Preface

The therapy of purulent meningitis is usually carried out first, if the pathogen is not known, against the suspected / most likely pathogen and after microbiological detection of the bacterium (this takes a few days until the bacterium can be grown and determined) and an antibiogram (resistance test of the Germ against various antibiotics).
The dosages mentioned are examples that can be treated differently in individual cases.
Despite all the care taken, the drugs mentioned below can contain errors in the dosage or other types of content.

Note: Compliance

Never change the dosage or antibiotic without consulting your doctor. This can permanently damage your health.

Therapy of purulent meningitis

Therapy meningococci

Penicillin G (G = intravenous, i.v.) 4x / day 6-10 mega or

Ampicillin 3x / day 5 g i.v. or

Cephalosporin (Ceftriaxone, Cefotaxime) 3x / day 2 g i.v.

Therapy pneumococci

Penicillin G (if sensitive): 4x / day 6-10 mega or

Cephalosporin (Ceftriaxone, Cefotaxime): 3x / day 2 g i.v. or

Ampicillin: 3x / day 5 g i.v.

Meropenem: 3x / day 2 g i.v.

Penicillin-Resistant Pneumococci

Cephalosporin plus Vancomycin 3x / day 2 g i.v. 2 g / day every 6 - 12 hours

Cephalosporin plus Rifampicin 3x / day 2 g i.v.

Therapy Haemophilus influenzae

Cephalosporin (Ceftriaxone, Cefotaxime) 3x / day 2 g i.v.

alternatively

Ampicillin plus chloramphenicol 3x / day 5 g i.v.

Therapy Listeria monocytogenes

Ampicillin plus gentamycin 3x / day 5 g i.v. or

Trimethoprim-sulfamethoxazole 1x / day 360 mg IV, max. 6 mg / kg or

Meropenem 3x / day 2 g i.v. or

Co-trimoxazole 2x / day 960 mg i.v.

Therapy staphylococci (methicillin-sensitive)

Flucloxacillin 4 - 6x / day 2 g i.v.

alternatively

Vancomycin 2g / day i.v. (every 6 - 12 hours 0.5 - 1 g) or

Fosfomycin 3x / day 5 g i.v. or

Rifampicin 1x / day 10 mg / kg IV, max. 600/750 mg or

Cefazolin 3 - 4x / day 2 - 3 g i.v. (max. 12 g / day)

Therapy staphylococci (methicillin-resistant)

Vancomycin 2g / day i.v. (every 6 - 12 h 0.5 - 1 g) or

Rifampicin 1x / day 10 mg / kg IV, max. 600/750 mg or

Trimethoprim-sulfamethoxazole or

Fosfomycin 3x / day 5 g i.v.

Therapy of Pseudomonas aeruginosa

Ceftazidime plus aminoglycoside 3x / day 2 g i.v. or

Meropenem plus aminoglycoside 3x / day 2 g i.v. or

Cefepime plus aminoglycoside 3x / day 2 g i.v. or

Ciprofloxacin 3x / day 400 mg i.v.

Therapy anaerobes

Metronidazole 2 - 4x / day 500 mg (max. 2 g / day)

Meropenem 3x / day 2 g i.v.

Therapy group B streptococci

Penicillin G plus gentamicin 4x / day 6-10 mega 1x / day 360 mg i.v. or

Ampicillin plus gentamycin 3x / day 5 g i.v. 1x / day 360 mg i.v. or

Ceftriaxone plus gentamicin 3x / day 2 g i.v. 1x / day 360 mg i.v. or

Vancomycin 2g / day i.v. (every 6 - 12 h 0.5 - 1 g)

Therapy Gram-negative intestinal bacteria

Ceftriaxone plus aminoglycoside 3x / day 2 g i.v.

Meropenem plus aminoglycoside 3x / day 2 g i.v.

Source

Poeck / Hacke: Neurologie, 12th edition, 2006 were used as sources.
Despite all the care that we take before a topic is published, we can take care of the information no guarantee take over.