Bonviva®
definition
Bonviva® is a drug from the bisphosphonate drug group. Bisphosphonates are also known as diphosphonates. It is a chemical compound with two phosphate groups. Bonviva® contains the active ingredient ibandronic acid (ibandronate).
Mechanism of action
The active ingredient ibandronic acid is one of the Bisphosphonate group, the in their chemical structure two phosphate atoms on one carbon atom have bound. As a result, they bind very well Hydroxyapatitewhat special often in the bone occurs. There they are specifically taken up by the cells that are responsible for the Bone loss are responsible. These cells are called Osteoclasts designated. By absorbing the active ingredient, the Osteoclasts specifically inhibited in their activity and thus the Breakdown of the bone substancewhich occurs increasingly in osteoporosis, prevented. As a result, the structure of the bone matrix can continue unhindered and the bone multiplies again. As for bone building calcium is needed, should there is no calcium deficiency.
dosage
The Drug Bonviva® is in the form of Tablets or pre-filled syringes available for regular injections. The patient can decide together with the doctor which form of application is most suitable for the patient. Injecting the drug would be an option for a patient with difficulty swallowing. The Syringes are already filled with 3 mg of the active ingredient ibandronic acid. The syringe will administered every three months. The general rule for the dosage is that it should be done in consultation with the doctor.
application areas
The active substance Ibandronic acid becomes very common for Treatment of bone loss (osteoporosis) in women applied in the menopause are located. Through the hormonal changes in postmenopausal women The risk of developing and multiplying osteoporosis also increases Fractures to draw.
Especially with women who are very early menopause can enter Risk can be significantly reduced. The drug Bonviva® can help reduce the risk of fractures. It has been shown that by taking Bonviva® the Number of lumbar vertebrae fractures decreased. On the other hand it was shown no improvement in femoral neck fractures. Furthermore, the drug can also be used for Therapy of bone metastases at Breast cancer patients can be used.
Side effects
Like all Medication can also do Bonviva® cause undesirable side effects that occur at different rates. To the Side effects uncommonly observed in patients could be count strong Chest pain such as while swallowing. Still came more often nausea, Vomit, malaise, a headache, Muscle spasms or Muscle tremors in front. Due to the effect of the drug on bone, it can too Bone, muscle and joint pain come.
The rarer side effects include besides itching and Eye pain also Swelling different areas like Face, lips, or tongue. If the patient is on himself during treatment with Bonviva® Side effects should he noticed these tell his doctor. The doctor can then decide whether it is necessary to discontinue the drug.
Interactions with other drugs
One appeared Complication of taking the drug, if polyvalent cations are also supplied at the same time were. There is an interaction in which stable and poorly absorbed complexes form. In addition, the Absorption continues to deteriorate. Furthermore should Bonviva® be taken on an empty stomach, so it should be about one half an hour before eating be taken. Care should also be taken two hours before and after taking the drug no calcium-rich foods or mineral supplements be taken.
Contraindications
The Drug Bonviva® should not be taken, when a allergy or Hypersensitivity to the active ingredient ibandronic acid it contains consists. In some cases it can become a Rash or even one allergic shock with a life-threatening situation.
In addition, ibandronic acid should not be used if the patient is having a low levels of calcium in the blood having. One then speaks of one Hypocalcemia. This should therefore be done before starting Bonviva treatment® to be eliminated first.
In addition, patients should discuss the intake with their doctor, if generally one Mineral metabolism disorder or one severe vitamin D deficiency present.
Even if the kidney function is impaired, for example by a known one Renal failure, should Bonviva® may not be used.
At The use of the drug is also contraindicated in children and adolescents. There are not yet any studies on the safety and effectiveness of use in persons aged 18 and under.
pregnancy and breast feeding period
So far the doctors and researchers are still doing this no facts known. However, the drug was tested on laboratory rats, which eventually developed a Showed reproductive toxicity of the drug. Hence it becomes one in humans too negative effect on the unborn child if taken during the pregnancy supposed. Bonviva® is therefore also Contraindicated in pregnant women.
It is also not known whether the Active ingredient ibandronic acid through breast milk into the child's circulation is passed on. There have also been attempts with this Laboratory rats, where one low concentration of the active ingredient in breast milk detected could be. For this reason, it is advisable to take Bonviva® not recommended for nursing mothers.
