Nasonex®

definition

Nasonex® is a drug that is often used as a nasal spray against allergic or inflammatory diseases in the nasopharynx.

The active ingredient contained is called Mometason and belongs to the group of highly effective glucocorticoids. Mometasone is also processed in ointments and creams and is used locally against allergic or inflammatory skin diseases such as psoriasis or neurodermatitis.

Mode of action

Glucocorticoids, the most famous representative of which is the Cortisone are used in countless diseases of the most varied types and work very well anti-inflammatory and immunosuppressive. That means that immune system is dampened and thus kept in check against an excessive, inappropriate reaction, which is used in allergic diseases.
The various other effects of glucocorticoids, which relate to all metabolic pathways in the body, can be neglected here, as Nasonex® only local is used and therefore cannot show any effects in the rest of the organism. Although it is absorbed through the mucous membranes, it is immediately broken down in the blood.

The effect of Nasonex® is mediated via the glucocorticoid receptor, whereupon a variety of reaction sequences are set in motion. On the one hand, there are the decreased education from inflammatory messengers like prostaglandins and histamine, which plays a central role in the allergic reaction, on the other hand increase on anti-inflammatory Fabrics.
The local application of Nasonex® allows targeted at the desired locations, e.g. in the nose hay feverto work and relieve symptoms such as itching, runny or blocked nose, persistent sneezing and general inflammation of the mucous membranes.
As described above, Nasonex® has no effect on the rest of the body. This is a great advantage, as does the Side effects avoided that can be expected with long systemic, i.e. more effective everywhere, administration. Nevertheless, you should consult a doctor if you take other glucocorticoid preparations in addition to Nasonex®.

Due to its additional effect of inhibiting the growth and reproduction of cells (antiproliferative), growth of the mucous membranes in the nasopharynx, the nasal polyps, can also be inhibited by Nasonex.

Areas of application

Nasonex has two main uses. The most important of these is the allergic one Rhinitiswho have favourited seasonal, arguably better than hay fever known, or can occur all year round.
As the name suggests, it is an allergic reaction in certain months Pollen or Grasses or without a temporal connection e.g. on Cat hair or House dust mites.
Nasonex is used successfully against the symptoms, not the disease itself. In children from 6 years Nasonex is approved for hay fever. It can if necessary nasal administered or, especially in known severe hay fever cases, up to 4 weeks in advance as Prevention.
Second, Nasonex is used in the treatment of Nasal polyps. these are benign Mucosal growths likely due to chronic Sinus infections are favored in their creation. Without any disease value, they can impede breathing and lead to secondary diseases. The antiproliferative The effect of Nasonex prevents further growth and lets the polyps shrink somewhat. The approval for this lies with young adults from 18 years, This form of application is unsuitable for children.

Contraindications

Not Nasonex® is to be used if you have an existing one infection in the nose because it weakens the body's local defenses. When a injury in the nose, it is also not advisable to use it, as glucocortocoids Disrupt wound healing.

dosage

The usual dose when used against allergic rhinitis, unless otherwise prescribed, is Two sprays once a day in each nostril, with each puff approx. 40 micrograms of the active ingredient. The usual dose for nasal polyps is the same as for hay fever, two sprays per nostril once a day.
Nasonex® comes in packs of 60 or 140 Sprays sold.