Nebilet®
General
Nebilet® is a prescription drug from the group of so-called "beta blockers". This group is used for various diseases of the cardiovascular system, but above all for high blood pressure and chronic poor performance of the heart (heart failure).
The active ingredient contained in Nebilet® is called Nebivolol. This is a 3rd generation beta blocker, i.e. a relatively young group with additional positive effects.
Mode of action
Nebilet® works by selectively blocking certain receptors in the body's regulatory system, the beta1 receptors. These are i.a. responsible for that Heart rate and performance, but can also be found in many other places in the body, such as in the kidneywhere the Blood pressure is regulated with. Now these receptors become by Nebilet® blockedso that the signal sent by the body does not arrive, this leads to several effects:
- Lowering the heart rate
The heart rate decreases and the heart also pumps less blood per stroke into the vessels. As a result it will less stressed and uses less energywhat to look for in treating a weak heart or the CHD, of the coronary artery disease, makes use of. Nebilet® also has a beneficial effect on you high blood pressure out. - Inhibiting the blood pressure increasing effect of the kidney
The long-term blood pressure lowering effect of Nebilet® is due to the fact that beta1 receptors in the kidney blocked. Here is an important center that increases blood pressure. A blockage at this point leads to a special mechanism long-term and more effective lowering of blood pressure.
- Vasodilation
It leads to a certain reaction sequence Release of the messenger substance Nitric oxide (NO) into the blood, which leads to an expansion of the blood vessels. This lowers blood pressure again.
After taking about 1-2 weeks a first blood pressure lowering effect becomes noticeable full potential is after about 4 weeks reached.
Area of application and contraindications
Nebilet® is mainly used in the therapy of High blood pressure and the chronic Heart failure. There is Nebilet® not the first choicebut will in case of intolerance to alternative drugs or given in addition to these.
Diseases that require treatment with Nebilet® to forbid:
1. Diabetes mellitus
Caution should be exercised if you have a comorbidity, the Diabetes mellitus, required. Nebilet® doesn't make the disease worse, but it does hides the natural Warning symptoms one Hypoglycaemia like sweating or Racing heart.
2. Low blood pressure (Hypotension) + Heart rate (Bradycardia)
You must not take Nebilet® if you low blood pressure or one low heart rate (<60 / min), as it has become one with the additional Beta1 blockade Cardiovascular breakdown can come.
3. Arrhythmias
Also certain Cardiac arrhythmias, the AV block 2nd and 3rd degrees exclude treatment with Nebilet®.
4. Circulatory disorders
Furthermore, circulatory disorders are like that peripheral arterial disease and the Raynaud's Syndrome, with which Close vessels spasmodically, Contraindications for Nebilet®.
5. Bronchial asthma
Because of possible muscle spasms in the lungs, these patients should not use beta blockers.
6. Bad liver values
Liver dysfunction also requires drug discontinuation.
7. Pregnancy
It must not be taken during pregnancy.
Side effects
When taking Nebilet® you are several side effects known that have already been observed, however mostly seldom are and do not have to occur with everyone. These include:
- slowed heart rate
- Nausea and headache
- Asthma attacks and
- partial fatigue
dose
Nebilet® is used in Tablet form administered at a dose of 5mg per tablet. It is not absolutely necessary to take the tablets with meals, but one should be taken regular intake to a specific time get used to.
It is important to know that you can take Nebilet® after a long period of administration never stop abruptly or should refuse to take it, as there is a so-called "Rebound phenomenon " can come. In a certain way, the body has adapted to the drug usedthat he was at the sudden absence of the active substance reacts with a drop in blood pressure and a slow heart rate, which can be dangerous. Therefore, one sneaks out Nebilet®, i.e. man reduce the dose until you finally get rid of it.
